Thank you again for meeting with us last Monday. Our discussion was constructive and allowed us to focus on short term objectives to meet expectations for the V/V report as well as elucidate long term expectations for the prototype. We have since communicated the notes of the meeting to our client representative.
Since then, the group has been focused on finalizing our design in CAD and modeling flow through the chamber in COMSOL. The group will be meeting later today to collaborate on the design and model and allocate work for the upcoming V/V report and presentation. I will be focused on refining the chamber design through changes which include an interlocking lid design to prevent inter-compartmental leakage between the chamber segments. Richard and Arnold will carry the responsibility of creating the COMSOL model. Best, David Sun
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During the brief meeting this week, the alternative cylindrical design that was discussed in last meeting was published in CAD and its dimensions were discussed in this week’s meeting as well.
Regarding the unibody design, we ran some experiments to improve the integrity of channel embedded in the gel to achieve the goal to maintain an open conduit for pressure driven flow. The measures that were taken during the experiments include increasing the channel size (radius), incubating the loaded gel (within testing chamber) under higher temperature and so on. Lastly, out group also discussed the future plan that to merge the features of two designs we are currently testing into one. Namely, after the improvement of conduit fabrication in the unibody design, the procedure shall be applied to the cylindrical design to improve its stability for diffusion measurement performance. In the end, attached are the top, middle and bottom compartment of the new cylindrical design. The top piece shall be holding the initial load of drug solution, the middle compartment shall be holding the gel (agarose, matrigel, etc.), the bottom piece shall serve the purpose of end fluid collection. More details of the design will be brought into next week’s report after more group discussions and experiments. Firstly, apologies for the tardy progress report. Our meeting with our client just ended (12:00PM).
In the meeting, we have discussed more alternatives to the design. We plan to revisit the cylindrical chamber design at the request of the client and plan to publish a CAD model by this weekend. Another point of discussion was the need for our group to seek out an expert. Because the point person on the project is no longer part of the lab, we agreed to begin seeking advice from experts in the field. Our group also plans on conducting another experiment with our prototype with stiffer agarose gel, something that was originally scheduled last semester but was not completed due to conflicts. Based on feedback from you on the progress report and presentation as well as advice from our client, we plan on editing our specific aims to better satisfy the requirements of the course. |
Group 38Archives
April 2017
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